The changing pneumococci: adapting to vaccination and transitioning between colonization and disease

Acronym: TransPneumo

FCT reference: PTDC/DTP-EPI/1555/2014

Principal investigator: J. Melo-Cristino

Dates: 01-04-2016 to 31-03-2019

Silva-Costa C, Brito MJ, Aguiar SI, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. 2019. Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015). Sci Rep 9:6. doi:10.1038/s41598-018-36799-x (PMID: 30626918)

Echániz-Aviles G, Guerreiro SI, Silva-Costa C, Mendes CI, Carriço JA, Carnalla-Barajas MN, Soto-Noguerón A, Velazquez-Meza ME, Melo-Cristino J, Luévanos-Velazquez A, Martínez-Medina L, Vázquez-Larios MDR, Ramirez M. 2019. Streptococcus pneumoniae serotype 3 in Mexico (1994-2017): decrease of the unusual CC4909 lineage post-PCV13 introduction. J Clin Microbiol. 57 e01354-18 doi:10.1128/JCM.01354-18 (PMID: 30404945)

Horácio AN, Silva-Costa C, Lopes E, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections. 2018. Conjugate vaccine serotypes persist as major causes of non-invasive pneumococcal pneumonia in Portugal despite declines in serotypes 3 and 19A (2012-2015). PLoS ONE 13:e0206912.doi:10.1371/journal.pone.0206912 (PMID: 30388168)

Silva-Costa C, Brito MJ, Pinho MD, Friães A, Aguiar SI, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. 2018. Pediatric complicated pneumonia caused by Streptococcus pneumoniae serotype 3 in 13-valent pneumococcal conjugate vaccinees, Portugal, 2010-2015. Emerging Infect Dis 24: 1307–1314. (PMID: 29912700)

Diamantino-Miranda J, Aguiar, SI, Carriço JA, Melo-Cristino J, Ramirez M. 2017. Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012. PLoS ONE 12:e0170354. (PMID: 28152029)

Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections. 2016. Serotype 3 remains the leading cause of invasive pneumococcal disease in adults in Portugal (2012-2014) despite continued reductions in other 13-valent conjugate vaccine serotypes. Front Microbiol 7:1616. (PMID: 27790208)

Horácio AN, Silva-Costa C, Diamantino-Miranda J, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections. 2016. Population structure of Streptococcus pneumoniae causing invasive disease in adults in Portugal before PCV13 availability for adults: 2008-2011. PLoS ONE 11:e0153602. (PMID: 27168156)

Silva-Costa C, Pinho M, Friães A, Gomes-Silva J, Guerreiro S, Brito M, Ramirez M, Melo-Cristino J. 2019. Molecular diagnostics reveals persistence of serotype 3 as the main cause of pediatric complicated pneumonia in Portugal despite extensive PCV13 use (P263), 18–21 September, 12th International Meeting on Microbial Epidemiological Markers (IMMEM XII) Dubrovnik, Croatia.

Gomes-Silva J, Silva-Costa C, Ramirez M, Melo-Cristino J. 2019. Characterization of the genetic lineages responsible for pediatric invasive pneumococcal disease in Portugal (1999-2015) (P267), 18–21 September, 12th International Meeting on Microbial Epidemiological Markers (IMMEM XII) Dubrovnik, Croatia.

C. Silva-Costa, J. Gomes-Silva, S. I. Guerreiro, L. Prados, M. J. Brito, M. Ramirez, J. Melo-Cristino, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 2019. Serotypes 3, 8 and 10A dominate among pediatric invasive pneumococcal infections in Portugal (2015-2018) (Oral) 14th European Meeting on the Molecular Biology of the Pneumococcus, 11th – 14th June, Greifswald, Germany.

C. Silva-Costa, M. D. Pinho, A. Friães, J. Gomes-Silva, S. I. Guerreiro, M.J. Brito, M. Ramirez, J. Melo-Cristino, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 2019. Three years after PCV13 introduction in the National Immunization Plan serotype 3 is still the main cause of complicated pneumonia in Portugal (P46) 14th European Meeting on the Molecular Biology of the Pneumococcus, 11th – 14th June, Greifswald, Germany.

Ramirez M. 2019. Maturing pneumococcal vaccination programs in children: implications for adult and at-risk group vaccination (Lecture). 4th Annual Dubai International Conference on Infectious Diseases and Vaccination, Dubai, UAE, 25-27th April.

Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections. 2018. Non-invasive pneumococcal pneumonia in adults in Portugal: continued decline of PCV13 serotypes (2015-2017) (P1452). IDWeek 2018. San Francisco, CA, USA, 3-7th October.

Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections. 2018. Serotypes 8 and 3 are the leading cause of invasive pneumococcal disease in adults in Portugal (2015-2017) (P1443). IDWeek 2018. San Francisco, CA, USA, 3-7th October.

Silva-Costa C, Horácio A, Aguiar SI, Lopes JP, Brito MJ, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. Persistence of PCV7 and PCV13 serotypes in pediatric invasive pneumococcal disease in Portugal after more than a decade of vaccine use (P278). 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11), Melbourne, Australia, 15-19 April 2018.

Silva-Costa C, Brito MJ, Pinho MD, Friães A, Aguiar SI, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. Serotype 3 is the leading cause of complicated pediatric pneumococcal pneumonia in Portugal even among PCV13 vaccinated children (2010-2015) (P279, oral). 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11), Melbourne, Australia, 15-19 April 2018.

Mendes CI, Machado M, Melo-Cristino J, Carriço JA, Ramirez M. Associations of serotype with characteristics of the spnD39III locus implicated in phase switching of pneumococci (P334). 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11), Melbourne, Australia, 15-19 April 2018.

Mendes CI, Machado MP, Melo-Cristino J, Ramirez M, Carriço JA. 2018. A mapping methodology for the characterization of modular genes (OP S2). Bioinformatics Open Days, Braga, Portugal, 15-16 March.

Silva-Costa C, Horácio A, Aguiar SI, Lopes JP, Brito MJ, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. 2017. Pediatric invasive pneumococcal disease in Portugal: changing epidemiology (2012-2016) (P172). MicroBioTec'17, Porto, Portugal, 7-9 December.

Mendes CI, Machado MP, Melo-Cristino J, Ramirez M, Carriço JA. 2017. Phase-variable type I restriction-modification systems: A new characterization methodology for high throughput sequencing data (P156). MicroBioTec'17, Porto, Portugal, 7-9 December.

Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections. 2017. Importance of vaccine serotypes and emergence of non-vaccine serotypes causing non-invasive pneumococcal pneumonia in adults in Portugal (2012-2015) (OS6-4). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

Silva-Costa C, Horácio A, Aguiar SI, Lopes JP, Brito MJ, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. 2017. PCV13 serotypes are still important causes of pediatric invasive pneumococcal disease in Portugal after more than a decade of conjugate vaccine (PS532). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

Ramirez M. 2017. Global burden of pneumococcal diseases (Invited lecture SP18-1). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

Silva-Costa C, Aguiar SI, Pinho MD, Friães A, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections, The Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 2017. Serotype distribution among Streptococcus pneumoniae isolates causing complicated pneumonia in children in Portugal (2010-2015) (P0059). 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, 22-25 April.

Silva-Costa C, Aguiar S, Pinho M, Friães A, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections, The Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. 2016. High prevalence of serotype 3 in pneumococcal isolates causing complicated pneumonia and empyema in Portugal (2010-2015) (20.169). International Meeting on Emerging Diseases and Surveillance (IMED 2016). Viena, Austria, 4th–7rd November.

Ramirez M. 2016. Novos serotipos: implicações na prática clínica. 13º encontro de Infecciologia Pediátrica - Novas ou velhas doenças? (Invited oral presentation), Coimbra, Portugal, 7th October.

Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections and The Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 2016. Serotypes and antimicrobial resistance of isolates causing invasive pneumococcal disease in adult patients in Portugal after the 13-valent conjugate vaccine received an adult indication - 2012-2014 (P789). IDWeek 2016. New Orleans, LA, USA, 26-30th October.

Silva-Costa C, Horácio AN, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections and The Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 2016. Isolates expressing PCV13 serotypes are still the leading cause of pediatric invasive pneumococcal disease in Portugal (P169). 10th International Symposium on Pneumococci and Pneumococcal Diseases – ISPPD10, Glasgow, Scotland, 26-30th June.

Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections. 2016. Serotype and antimicrobial resistance of isolates causing invasive pneumococcal disease in adults in Portugal (2012-2014) (P630). 10th International Symposium on Pneumococci and Pneumococcal Diseases – ISPPD10, Glasgow, Scotland, 26-30th June.