✎ pip:fct1555_2014 [Molecular Microbiology and Infection Unit]

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====== The changing pneumococci: adapting to vaccination and transitioning between colonization and disease ======

Acronym: TransPneumo

FCT reference: PTDC/DTP-EPI/1555/2014

Principal investigator: J. Melo-Cristino

Dates: 01-04-2016 to 31-03-2019

===== Summary =====


===== Publications =====

==== Papers ====

[[people:jmiranda|Diamantino-Miranda J]], [[people:siaguiar|Aguiar, SI]], [[people:jcarrico|Carriço JA]], [[people:jmelocristino|Melo-Cristino J]], [[people:ramirez|Ramirez M]]. 2017. <fc #0000FF>Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012</fc>. PLoS ONE 12:e0170354. [[http://www.ncbi.nlm.nih.gov/pubmed/28152029|(PMID: 28152029)]]

[[people:ahoracio|Horácio AN]], [[people:anacosta|Silva-Costa C]], Lopes JP, [[people:ramirez|Ramirez M]], [[people:jmelocristino|Melo-Cristino J]], Portuguese Group for the Study of Streptococcal Infections. 2016. <fc #0000FF>Serotype 3 remains the leading cause of invasive pneumococcal disease in adults in Portugal (2012-2014) despite continued reductions in other 13-valent conjugate vaccine serotypes</fc>. Front Microbiol 7:1616. [[http://www.ncbi.nlm.nih.gov/pubmed/27790208|(PMID: 27790208)]]

==== Meeting presentations ====

**Mendes CI, Machado MP, Melo-Cristino J, Ramirez M, Carriço JA.** 2018. A mapping methodology for the characterization of modular genes (OP S2). Bioinformatics Open Days, Braga, Portugal, 15-16 March.

**Silva-Costa C, Horácio A, Aguiar SI, Lopes JP, Brito MJ, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society.** Pediatric invasive pneumococcal disease in Portugal: changing epidemiology (2012-2016) (P172). MicroBioTec'17, Porto, Portugal, 7-9 December.

**Mendes CI, Machado MP, Melo-Cristino J, Ramirez M, Carriço JA.** Phase-variable type I restriction-modification systems: A new characterization methodology for high throughput sequencing data (P156). MicroBioTec'17, Porto, Portugal, 7-9 December.

**Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections.** 2017. Importance of vaccine serotypes and emergence of non-vaccine serotypes causing non-invasive pneumococcal pneumonia in adults in Portugal (2012-2015) (OS6-4). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

**Silva-Costa C, Horácio A, Aguiar SI, Lopes JP, Brito MJ, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society.** 2017. PCV13 serotypes are still important causes of pediatric invasive pneumococcal disease in Portugal after more than a decade of conjugate vaccine (PS532). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

**Ramirez M.** 2017. Global burden of pneumococcal diseases (Invited lecture SP18-1). International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan, 24-27th November.

**Silva-Costa C, Aguiar SI, Pinho MD, Friães A, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections, The Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society.** 2017. Serotype distribution among //Streptococcus pneumoniae// isolates causing complicated pneumonia in children in Portugal (2010-2015) (P0059). 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, 22-25 April.


**Silva-Costa C, Aguiar S, Pinho M, Friães A, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections, The Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society**. 2016. High prevalence of serotype 3 in pneumococcal isolates causing complicated pneumonia and empyema in Portugal (2010-2015) (20.169). International Meeting on Emerging Diseases and Surveillance (IMED 2016). Viena, Austria, 4th–7rd November.

**Ramirez M**. 2016. Novos serotipos: implicações na prática clínica. 13º encontro de Infecciologia Pediátrica - Novas ou velhas doenças? (Invited oral presentation), Coimbra, Portugal, 7th October.

**Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections and The  Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society**. 2016. Serotypes and antimicrobial resistance of isolates causing invasive pneumococcal disease in adult patients in Portugal after the 13-valent conjugate vaccine received an adult indication - 2012-2014 (P789). IDWeek 2016. New Orleans, LA, USA, 26-30th October.

**Silva-Costa C, Horácio AN, Lopes JP, Ramirez M, Melo-Cristino J, The Portuguese Group for the Study of Streptococcal Infections and The  Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society**. 2016. Isolates expressing PCV13 serotypes are still the leading cause of pediatric invasive pneumococcal disease in Portugal (P169). 10th International Symposium on Pneumococci and Pneumococcal Diseases – ISPPD10, Glasgow, Scotland, 26-30th June.

**Horácio AN, Silva-Costa C, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections.** 2016. Serotype and antimicrobial resistance of isolates causing invasive pneumococcal disease in adults in Portugal (2012-2014) (P630). 10th International Symposium on Pneumococci and Pneumococcal Diseases – ISPPD10, Glasgow, Scotland, 26-30th June.