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people:anacosta [2014/04/09 10:35]
anacosta [Bio]
people:anacosta [2018/12/20 12:43] (current)
anacosta [Research Interests]
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 ===== Research Interests ===== ===== Research Interests =====
  
-My current work focuses the molecular epidemiology of //​Streptococcus ​pyogenes// associated with non-invasive infection. I am interested in the clonal composition of the population of //S. pyogenes// isolated in Portuguese Hospitalsgiving ​special attention to the macrolide-resistant strainssince antimicrobial resistance is a problem ​of major concern +My current work focuses the molecular epidemiology of //​Streptococcus ​pneumoniae// associated with invasive and non-invasive infection. I am particularly ​interested in the clonal composition of the population of //S. pneumoniae// isolated in childrenwith special attention to the invasive infectionsand in the evaluation ​of the impact of the use of pneumococcal conjugate vaccines in this age group, on the serotype distribution and epidemiology of this important pathogen. I am also involved on the molecular diagnosis of complicated pneumonias, also in children, mainly caused by //S. pneumoniae//​
  
 ===== Websites ===== ===== Websites =====
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 ===== Publications ===== ===== Publications =====
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 +C. Silva-Costa,​ J. A. Carriço, M. Ramirez, and J. Melo-Cristino. 2014. Scarlet fever is caused by a limited number of Streptococcus pyogenes lineages and is associated with the exotoxin genes ssa, speA and speC. Pediatr Infect Dis J. 33(3):​306-10. (PMID: 24168973)
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 +A. Friães, Pinto FR, C. Silva-Costa,​ M. Ramirez, J. Melo-Cristino 2013. Superantigen gene complement of Streptococcus pyogenes - relationship with other typing methods and short-term stability. Eur. J. Clin. Microbiol. Infect. Dis. 32:115-125. (PMID: 22936424)
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 +A. Friães, Pinto FR, C. Silva-Costa,​ M. Ramirez, J. Melo-Cristino,​ The Portuguese Group for the Study of Streptococcal Infections. 2012. Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance. BMC Microbiol. 12:​280.(PMID:​ 23181337)
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 +C. Silva-Costa,​ A. Friães, M. Ramirez, J. Melo-Cristino,​ The Portuguese Group for the Study of Streptococcal Infections. 2012. Differences between macrolide resistant and susceptible Streptococcus pyogenes: the importance of clonal properties in addition to antibiotic consumption. Antimicrob Agents Chemother. 56:​5661–5666. (PMID: 22908153)
  
 Silva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J. and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. “Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 14:​1152-1159 Silva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J. and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. “Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 14:​1152-1159
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