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people:anacosta [2009/09/10 11:40]
anacosta
people:anacosta [2018/12/20 12:43] (current)
anacosta [Research Interests]
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 ====== catarina silva-costa ====== ====== catarina silva-costa ======
 ====== ​ ====== ====== ​ ======
-{{:​people:​foto_sandra_aguiar_2.jpg|}}+
  
 ===== Bio ===== ===== Bio =====
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 **Academic Qualification**: ​ **Academic Qualification**: ​
 +  * Degree: Biochemistry - FC/UL\\
   * Master Degree: Clinical Microbiology - FML/UL\\   * Master Degree: Clinical Microbiology - FML/UL\\
-  * Degree: Biochemistry ​FCL/UL\\+  * PhD in Microbiology ​Faculdade de Medicina, ​UL\\
    
- 
 ===== Current Position ===== ===== Current Position =====
-**Teaching ​Assistant**\\ ​+**Assistant ​Professor**\\ 
 Instituto de Microbiologia,​[[http://​www.fm.ul.pt/​|Faculdade de Medicina de Lisboa]], Universidade de Lisboa\\ ​ Instituto de Microbiologia,​[[http://​www.fm.ul.pt/​|Faculdade de Medicina de Lisboa]], Universidade de Lisboa\\ ​
  
 ===== Research Interests ===== ===== Research Interests =====
  
-In the last five years I have been interested in the molecular epidemiology of //​Streptococcus pneumoniae//​ associated with infection. //S. pneumoniae// ​is recognized as an important cause of morbidity and mortality especially among pre-school ​children. Nevertheless this pathogen is also a normal colonizer of the nasopharynx ​of healthy individuals. The aim of the study is to characterize ​pneumococcal ​strains isolated from infectionsusing several phenotypic ​and genotypic methodologies,​ and identify characteristics ​of more virulent strains for further studies such as host-pathogen ​interaction.\\ +My current work focuses ​the molecular epidemiology of //​Streptococcus pneumoniae//​ associated with invasive and non-invasive ​infection. ​I am particularly interested in the clonal composition of the population of //S. pneumoniae// ​isolated in children, with special attention to the invasive infections, and in the evaluation ​of the impact ​of the use of pneumococcal ​conjugate vaccines in this age groupon the serotype distribution ​and epidemiology ​of this important ​pathogen. ​I am also involved on the molecular diagnosis of complicated pneumonias, also in children, mainly caused by //S. pneumoniae//​. ​
  
 ===== Websites ===== ===== Websites =====
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 ===== Publications ===== ===== Publications =====
 +
 +
 +C. Silva-Costa,​ J. A. Carriço, M. Ramirez, and J. Melo-Cristino. 2014. Scarlet fever is caused by a limited number of Streptococcus pyogenes lineages and is associated with the exotoxin genes ssa, speA and speC. Pediatr Infect Dis J. 33(3):​306-10. (PMID: 24168973)
 +
 +A. Friães, Pinto FR, C. Silva-Costa,​ M. Ramirez, J. Melo-Cristino 2013. Superantigen gene complement of Streptococcus pyogenes - relationship with other typing methods and short-term stability. Eur. J. Clin. Microbiol. Infect. Dis. 32:115-125. (PMID: 22936424)
 +
 +A. Friães, Pinto FR, C. Silva-Costa,​ M. Ramirez, J. Melo-Cristino,​ The Portuguese Group for the Study of Streptococcal Infections. 2012. Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance. BMC Microbiol. 12:​280.(PMID:​ 23181337)
 +
 +C. Silva-Costa,​ A. Friães, M. Ramirez, J. Melo-Cristino,​ The Portuguese Group for the Study of Streptococcal Infections. 2012. Differences between macrolide resistant and susceptible Streptococcus pyogenes: the importance of clonal properties in addition to antibiotic consumption. Antimicrob Agents Chemother. 56:​5661–5666. (PMID: 22908153)
 +
 +Silva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J. and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. “Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 14:​1152-1159
 +
 +Carriço, J. A., C. Silva-Costa,​ J. Melo-Cristino,​ F. R. Pinto, H. de Lencastre, J. S. Almeida, M. Ramirez. 2006. “Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes”. J. Clin. Microbiol. 44:​2524-2532
 +
 +Silva-Costa,​ C., J. Melo-Cristino and M. Ramirez. 2005. “Identification of macrolide-resistant clones of Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 12:513-518.
 +
 +Silva-Costa,​ C., J. Melo-Cristino and M. Ramirez. 2005. Rapid inversion of the prevalences of macrolide resistance phenoypes paralleled by a diversification of T and emm types among Streptococcus pyogenes in Portugal. Antimicrob. Agents Chemother. 49:2109-21
  
  
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