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people:anacosta [2014/04/09 10:38] anacosta [Publications] |
people:anacosta [2018/12/20 12:42] anacosta [Research Interests] |
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===== Research Interests ===== | ===== Research Interests ===== | ||
- | My current work focuses the molecular epidemiology of //Streptococcus pyogenes// associated with non-invasive infection. I am interested in the clonal composition of the population of //S. pyogenes// isolated in Portuguese Hospitals, giving special attention to the macrolide-resistant strains, since antimicrobial resistance is a problem of major concern. | + | My current work focuses the molecular epidemiology of //Streptococcus pneumoniae// associated with invasive and non-invasive infection. I am particularly interested in the clonal composition of the population of //S. pneumoniae// isolated in children , with special attention to the invasive infections, and to evaluate the impact of the use of pneumococcal conjugate vaccines in the serotype distribution and epidemiology of this important pathogen. I am also involved on the molecular diagnosis of complicated pneumonias, also in children, mainly caused by //S. pneumoniae//. |
===== Websites ===== | ===== Websites ===== | ||
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===== Publications ===== | ===== Publications ===== | ||
- | A. Friães, Pinto FR, C. Silva-Costa, M. Ramirez, J. Melo-Cristino 2013. Superantigen gene complement of Streptococcus pyogenes - relationship with other typing methods and short-term stability. Eur. J. Clin. Microbiol. Infect. Dis. 32:115-125. (PMID: 22936424) | ||
C. Silva-Costa, J. A. Carriço, M. Ramirez, and J. Melo-Cristino. 2014. Scarlet fever is caused by a limited number of Streptococcus pyogenes lineages and is associated with the exotoxin genes ssa, speA and speC. Pediatr Infect Dis J. 33(3):306-10. (PMID: 24168973) | C. Silva-Costa, J. A. Carriço, M. Ramirez, and J. Melo-Cristino. 2014. Scarlet fever is caused by a limited number of Streptococcus pyogenes lineages and is associated with the exotoxin genes ssa, speA and speC. Pediatr Infect Dis J. 33(3):306-10. (PMID: 24168973) | ||
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+ | A. Friães, Pinto FR, C. Silva-Costa, M. Ramirez, J. Melo-Cristino 2013. Superantigen gene complement of Streptococcus pyogenes - relationship with other typing methods and short-term stability. Eur. J. Clin. Microbiol. Infect. Dis. 32:115-125. (PMID: 22936424) | ||
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+ | A. Friães, Pinto FR, C. Silva-Costa, M. Ramirez, J. Melo-Cristino, The Portuguese Group for the Study of Streptococcal Infections. 2012. Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance. BMC Microbiol. 12:280.(PMID: 23181337) | ||
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+ | C. Silva-Costa, A. Friães, M. Ramirez, J. Melo-Cristino, The Portuguese Group for the Study of Streptococcal Infections. 2012. Differences between macrolide resistant and susceptible Streptococcus pyogenes: the importance of clonal properties in addition to antibiotic consumption. Antimicrob Agents Chemother. 56:5661–5666. (PMID: 22908153) | ||
Silva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J. and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. “Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 14:1152-1159 | Silva-Costa C, Pinto FR, Ramirez M, Melo-Cristino J. and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. “Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal”. Clin. Microbiol. Infect. 14:1152-1159 |